SCHEMBL7075974

SCHEMBL7075974

Cc1ccc(-c2nc3c[nH]c(N)nc-3n2)nc1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 1/20 0.47
CCR5 P51681 1/20 0.47
CCR8 P51685 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
NOS3 P29474 1/20 0.40
NOS2 P35228 1/20 0.40
METAP2 P50579 1/20 0.40
CYP3A4 P08684 1/20 0.36
CYP2A6 P11509 1/20 0.36
ADORA2A P29274 1/20 0.33
ADORA1 P30542 1/20 0.33
MERTK Q12866 1/20 0.32
GRM5 P41594 1/20 0.31
ADRA2A P08913 2/20 0.31
ADRA2B P18089 2/20 0.31
ADRA2C P18825 2/20 0.31
PLAU P00749 1/20 0.31
TGFBR1 P36897 1/20 0.30
PTGS2 P35354 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12622282 0.80 CCR1 (0.71) CCR1CCR5CCR8HDAC6NOS3
SCHEMBL20390545 0.77 CCR1 (0.50) CCR1CCR5CCR8HDAC6NOS3
SCHEMBL12628191 0.72 CCR1 (0.58) CCR1CCR5CCR8HDAC6NOS3
SCHEMBL12628177 0.72 CCR1 (0.58) CCR1CCR5CCR8HDAC6NOS3
SCHEMBL12628200 0.71 CCR1 (0.70) CCR1CCR5CCR8HDAC6NOS3
SCHEMBL12628224 0.69 CCR1 (0.54) CCR1CCR5CCR8HDAC6METAP2
SCHEMBL12628229 0.69 KDM4E (0.67) CCR1CCR5CCR8HDAC6METAP2
SCHEMBL6942143 0.69 CYP2A6 (0.37) CYP3A4CYP2A6
SCHEMBL17051506 0.68 CCR1 (0.71) CCR1CCR5CCR8HDAC6NOS3
SCHEMBL26721041 0.68 CCR1 (0.71) CCR1CCR5CCR8HDAC6NOS3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1349857-A1 PURINE DERIVATIVES AS PURINERGIC RECEPTOR ANTAGONISTS VERNALIS RESEARCH LIMITED (GB) 2003-10-08 EP disclosed
WO-2002055521-A1 PURINE DERIVATIVES AS PURINERGIC RECEPTOR ANTAGONISTS VERNALIS RESEARCH LIMITED (GB) 2002-07-18 WO disclosed