Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | YAP1 | P46937 | 1/20 | 0.56 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.56 |
| ▸ | GPR183 | P32249 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076837 | 1.00 | TSHR (0.65) | TSHRALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL7222883 | 0.84 | TSHR (0.71) | TSHRALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL18864777 | 0.84 | TSHR (0.71) | TSHRALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL6794763 | 0.84 | MAPT (0.55) | TSHRALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL6794767 | 0.84 | MAPT (0.55) | TSHRALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL30047393 | 0.83 | TSHR (0.69) | TSHRALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL21593709 | 0.83 | TSHR (0.69) | TSHRALDH1A1KMT2AMEN1LMNA | |
| Hydrochloric Acid SCHEMBL6194545 | 0.83 | MAPT (0.54) | TSHRALDH1A1KMT2AMEN1LMNA | |
| Hydrochloric Acid SCHEMBL6194541 | 0.83 | MAPT (0.54) | TSHRALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL5736533 | 0.81 | TSHR (0.44) | TSHRALDH1A1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |
| EP-1025086-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GmbH (DE) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999016751-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 1999-04-08 | — | — | WO | disclosed |