Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 20/20 | 0.71 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.71 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.71 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.71 |
| ▸ | F10 | P00742 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5854771 | 0.85 | F2 (0.78) | F2PRSS1 | |
| SCHEMBL6957150 | 0.85 | F2 (0.75) | F2PRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL7456976 | 0.84 | F2 (0.66) | F2PRSS1PRSS2PRSS3F10 | |
| Hydrochloric Acid SCHEMBL6952739 | 0.83 | F2 (0.98) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7403758 | 0.81 | F2 (0.61) | F2 | |
| SCHEMBL5855829 | 0.77 | F2 (0.68) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL7445979 | 0.75 | F2 (0.84) | F2PRSS1 | |
| SCHEMBL7643508 | 0.75 | F2 (0.84) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL6957416 | 0.74 | F2 (0.70) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL8293370 | 0.73 | F2 (0.67) | F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189899-B1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO INC (US) | 2003-02-12 | — | — | EP | disclosed |
| US-6455532-B1 | ANTICOAGULANTS | MERCK & CO., INC. | 2002-09-24 | — | — | US | disclosed |
| EP-1189899-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000075134-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2000-12-14 | — | — | WO | disclosed |