SCHEMBL7077958

SCHEMBL7077958

Cc1cc(=O)n(C(C)C)c2nc(Nc3ccc(N4CCNCC4)cc3)ncc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 19/20 1.00
CCND1 P24385 17/20 1.00
CCND3 P30281 15/20 1.00
CCND2 P30279 14/20 1.00
CCNA2 P20248 4/20 0.72
CDK2 P24941 4/20 0.72
FGFR1 P11362 3/20 0.70
FGFR2 P21802 3/20 0.70
FGFR4 P22455 3/20 0.70
FGFR3 P22607 3/20 0.70
NUAK1 O60285 2/20 0.70
CDK1 P06493 3/20 0.57
CCNB1 P14635 3/20 0.57
CCNB2 O95067 2/20 0.57
CCNB3 Q8WWL7 2/20 0.57
CCNE2 O96020 1/20 0.57
CCNE1 P24864 1/20 0.57
CCNA1 P78396 1/20 0.57
MARK3 P27448 1/20 0.56
MARK2 Q7KZI7 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL7079190 0.92 CDK4 (0.85) CDK4CCND1CCND3CCND2CCNA2
SCHEMBL7175584 0.89 CDK4 (0.80) CDK4CCND1CCND3CCND2CCNA2
SCHEMBL6940711 0.87 CDK4 (0.77) CDK4CCND1CCND3CCND2CCNA2
SCHEMBL7071401 0.84 CDK4 (0.72) CDK4CCND1CCND3CCND2CCNA2
SCHEMBL6942982 0.84 CDK4 (0.72) CDK4CCND1CCND3CCND2CCNA2
SCHEMBL6940086 0.83 CDK4 (0.74) CDK4CCND1CCND3CCND2CCNA2
SCHEMBL6944231 0.82 CDK4 (1.00) CDK4CCND1CCND3CCND2CCNA2
Trifluoroacetic Acid SCHEMBL6940183 0.82 CDK4 (0.69) CDK4CCND1CCND3CCND2CCNA2
SCHEMBL7071397 0.81 CDK4 (0.98) CDK4CCND1CCND3CCND2CCNA2
Hydrochloric Acid SCHEMBL6938660 0.79 CDK4 (0.98) CDK4CCND1CCND3CCND2CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1268476-A1 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS WARNER-LAMBERT COMPANY (US) 2003-01-02 EP claimed
WO-2001070741-A1 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS WARNER-LAMBERT COMPANY (US) 2001-09-27 WO claimed