Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.54 |
| ▸ | VEGFA | P15692 | 4/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14900099 | 0.82 | EGLN1 (0.69) | MAPK14VEGFAEGLN1TP53LMNA | |
| SCHEMBL5341956 | 0.75 | SMN1; SMN2 (0.50) | MAPK14LMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4470835 | 0.74 | MAPK14 (0.57) | MAPK14VEGFAEGLN1TP53THRB | |
| SCHEMBL28486488 | 0.73 | MAPK14 (0.60) | MAPK14VEGFAEGLN1TP53LMNA | |
| SCHEMBL16281890 | 0.72 | EGLN1 (0.60) | MAPK14VEGFAEGLN1TP53LMNA | |
| SCHEMBL4469481 | 0.72 | MAPK14 (0.55) | MAPK14VEGFAEGLN1TP53THRB | |
| SCHEMBL18347240 | 0.71 | MAPK14 (0.56) | MAPK14TP53LMNAKDM4EMEN1 | |
| SCHEMBL12594186 | 0.71 | MAPK14 (0.71) | MAPK14EGLN1TP53KDM4EMEN1 | |
| SCHEMBL4382314 | 0.71 | MAPK14 (0.57) | MAPK14VEGFAEGLN1TP53LMNA | |
| SCHEMBL12598814 | 0.71 | EGLN1 (0.68) | MAPK14VEGFAEGLN1TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871625-B1 | PREPARATION OF TRIAZOLES BY ORGANOMETALLIC ADDITION TO KETONES AND INTERMEDIATES THEREFOR | PFIZER RES ANDDEVELOPMENT COMP (IE) | 2003-12-17 | — | — | EP | disclosed |