Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074778 | 0.89 | HTR1B (0.56) | HTR1BHTR2BGPR65KDM4ENPSR1 | |
| Fumaric Acid SCHEMBL7074139 | 0.86 | HTR1B (0.50) | HTR1BHTR2BGPR65KDM4ENPSR1 | |
| Maleic Acid SCHEMBL7074136 | 0.86 | HTR1B (0.50) | HTR1BHTR2BGPR65KDM4ENPSR1 | |
| SCHEMBL5748124 | 0.85 | HTR1B (0.62) | HTR1BHTR2BGPR65KDM4ENPSR1 | |
| Maleic Acid SCHEMBL5745874 | 0.82 | HTR1B (0.51) | HTR1BHTR2BGPR65KDM4ENPSR1 | |
| Fumaric Acid SCHEMBL5745877 | 0.82 | HTR1B (0.51) | HTR1BHTR2BGPR65KDM4ENPSR1 | |
| SCHEMBL7076008 | 0.82 | HTR1B (0.56) | HTR1BHTR2BGPR65NPSR1ADORA2A | |
| SCHEMBL5745878 | 0.82 | HTR1B (0.67) | HTR1BHTR2BGPR65KDM4ENPSR1 | |
| Hydrochloric Acid SCHEMBL5776576 | 0.81 | HTR1B (0.60) | HTR1BHTR2BGPR65KDM4ENPSR1 | |
| SCHEMBL5750023 | 0.81 | HTR1B (0.63) | HTR1BHTR2BGPR65TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1321169-A1 | Combination of a serotonin receptor antagonist with a histidine decarboxylase inhibitor as a medicament | Biofrontera Pharmaceuticals AG (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-5958934-A | 5-HT 2B ANTAGONIST | SYNTEX (U.S.A.) INC. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5952331-A | SELECTIVE 5HT2B ANTAGONISTS; SEROTONIN RECEPTOR ANTAGONIST; TREATING DISORDERS OF THE GASTROINTESTINAL TRACK, RESTENOSIS, ASTHMA AND OBSTRUCTIVE AIRWAY DISEASE, PROSTATIC HYPERPLASIA, GENERALIZED ANXIETY, PANIC DISORDER | SYNTEX (USA) INC. (US) | 1999-09-14 | — | — | US | disclosed |
| US-5863924-A | Aryl pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1999-01-26 | — | — | US | disclosed |