Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.54 |
| ▸ | GRM4 | Q14833 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7079846 | 1.00 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7079512 | 0.85 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7079509 | 0.85 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7082605 | 0.84 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7076132 | 0.84 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7081913 | 0.83 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7081916 | 0.83 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL5173645 | 0.83 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7081239 | 0.83 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11NPC1 | |
| SCHEMBL7081236 | 0.83 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030073832-A1 | Novel aminophenyl ketone derivatives | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2003-04-17 | — | — | US | claimed |
| US-20030073832-A1 | Novel aminophenyl ketone derivatives | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2003-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073832-A1 | Novel aminophenyl ketone derivatives | MAPKAPK2, MAP3K2, MAP3K1 | MAPK14 28/4885MAPK13 33/4885MAPK12 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.