Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.49 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.49 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | L3MBTL3 | Q96JM7 | 6/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.45 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.45 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1334264 | 0.84 | MEN1 (0.68) | MEN1KMT2AGNAI3GNAO1GNAI1 | |
| SCHEMBL28230108 | 0.82 | ATM (0.71) | MEN1KMT2AGNAI3GNAO1GNAI1 | |
| SCHEMBL11769367 | 0.82 | ATM (0.71) | MEN1KMT2AGNAI3GNAO1GNAI1 | |
| SCHEMBL727823 | 0.81 | ATM (0.68) | MEN1KMT2AGNAI3GNAI1ATM | |
| SCHEMBL727385 | 0.81 | ATM (0.68) | MEN1KMT2AGNAI3GNAI1ATM | |
| SCHEMBL2695810 | 0.81 | ATM (0.68) | MEN1KMT2AGNAI3GNAI1ATM | |
| SCHEMBL727876 | 0.81 | ATM (0.68) | MEN1KMT2AGNAI3GNAI1ATM | |
| SCHEMBL729126 | 0.81 | ATM (0.68) | MEN1KMT2AGNAI3GNAI1ATM | |
| SCHEMBL251937 | 0.81 | ATM (0.68) | MEN1KMT2AGNAI3GNAI1ATM | |
| SCHEMBL1160274 | 0.81 | ATM (0.68) | MEN1KMT2AGNAI3GNAI1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268454-A1 | SUCCINOYLAMINO HETEROCYCLES AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074796-A1 | SUCCINOYLAMINO HETEROCYCLES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-10-11 | — | — | WO | disclosed |