Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.61 |
| ▸ | SKP1 | P63208 | 1/20 | 0.61 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.61 |
| ▸ | SYK | P43405 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | SMO | Q99835 | 1/20 | 0.45 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30931884 | 0.88 | CKS1B (0.61) | CKS1BSKP1SKP2SYKRET | |
| SCHEMBL21564581 | 0.88 | CKS1B (0.61) | CKS1BSKP1SKP2SYKRET | |
| SCHEMBL530038 | 0.88 | CKS1B (0.61) | CKS1BSKP1SKP2SYKRET | |
| SCHEMBL29518126 | 0.87 | CKS1B (0.60) | CKS1BSKP1SKP2SYKRET | |
| SCHEMBL21360327 | 0.87 | CKS1B (0.60) | CKS1BSKP1SKP2SYKRET | |
| SCHEMBL23323204 | 0.87 | CKS1B (0.60) | CKS1BSKP1SKP2SYKRET | |
| SCHEMBL28666722 | 0.87 | CKS1B (0.60) | CKS1BSKP1SKP2SYKRET | |
| SCHEMBL3025692 | 0.87 | CKS1B (0.60) | CKS1BSKP1SKP2SYKRET | |
| SCHEMBL31722428 | 0.87 | CKS1B (0.60) | CKS1BSKP1SKP2SYKRET | |
| SCHEMBL6139645 | 0.86 | CKS1B (0.61) | CKS1BSKP1SKP2SYKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649627-B1 | N-Substituted with 1- (pyrid-2-yl)-piperidine-4-yl radical; gastrointestinal and psychological disorder treatment; antidiabetic tocolytic, and antidepressant agents; irritable bowel syndrome, glaucoma and dysmenorrhoea | SANOFI-SYNTHELABO (FR) | 2003-11-18 | — | — | US | disclosed |