⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2040426 | 0.59 | — | — | |
| SCHEMBL14612064 | 0.57 | — | — | |
| SCHEMBL357257 | 0.57 | — | — | |
| SCHEMBL12160740 | 0.57 | — | — | |
| SCHEMBL9215243 | 0.57 | — | — | |
| SCHEMBL3555788 | 0.56 | — | — | |
| SCHEMBL20614486 | 0.55 | CREBBP (0.52) | — | |
| SCHEMBL13233500 | 0.54 | TSHR (0.38) | — | |
| SCHEMBL2535119 | 0.54 | — | — | |
| SCHEMBL5709556 | 0.54 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783507-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-10-10 | — | — | US | disclosed |
| US-20170137388-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-05-18 | — | — | US | disclosed |
| US-9593110-B2 | Neprilysin inhibitors | Theravence Biopharma R&D IP, LLC (US) | 2017-03-14 | — | — | US | disclosed |
| WO-2015116786-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-08-06 | — | — | WO | disclosed |
| US-20150210690-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-07-30 | — | — | US | disclosed |
| WO-2009119858-A1 | BENZENE COMPOUND, AND USE THEREOF FOR MEDICAL PURPOSES | 田辺三菱製薬株式会社 (JP) | 2009-10-01 | — | — | WO | disclosed |
| EP-1324996-A2 | SUBSTITUTED ARYL KETONES | Bayer CropScience AG (DE) | 2003-07-09 | — | — | EP | disclosed |
| WO-2001053275-A2 | SUBSTITUTED ARYL KETONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-07-26 | — | — | WO | disclosed |