Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 4/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.48 |
| ▸ | F9 | P00740 | 2/20 | 0.44 |
| ▸ | PLAU | P00749 | 2/20 | 0.42 |
| ▸ | F10 | P00742 | 2/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7075541 | 0.85 | F10 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7082839 | 0.79 | F10 (0.53) | F10 | |
| SCHEMBL7076322 | 0.79 | F10 (0.51) | F10 | |
| SCHEMBL2073671 | 0.77 | F9 (0.44) | F9PLAUF10 | |
| SCHEMBL7135037 | 0.76 | F10 (0.48) | F10 | |
| SCHEMBL5407681 | 0.75 | MAPT (0.44) | F9F10 | |
| Trifluoroacetic Acid SCHEMBL7080631 | 0.74 | F10 (0.56) | F10 | |
| SCHEMBL7079506 | 0.74 | F10 (0.50) | F10 | |
| SCHEMBL2070976 | 0.74 | F10 (0.41) | F9F10 | |
| SCHEMBL2070901 | 0.73 | F10 (0.51) | F9F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322618-A1 | AMINO HETEROCYCLIC COMPOUNDS (FACTOR X A? INHIBITORS 14) | MERCK PATENT GmbH (DE) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024654-A1 | AMINO HETEROCYCLIC COMPOUNDS (FACTOR XA INHIBITORS 14) | MERCK PATENT GMBH (DE) | 2002-03-28 | — | — | WO | disclosed |