Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 2/20 | 0.31 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL381925 | 0.91 | — | — | |
| SCHEMBL381924 | 0.91 | — | — | |
| SCHEMBL847380 | 0.84 | MAPT (0.48) | MAPTABCC4ALDH1A1LMNAUSP2 | |
| SCHEMBL847381 | 0.84 | MAPT (0.48) | MAPTABCC4ALDH1A1LMNAUSP2 | |
| SCHEMBL7647084 | 0.82 | MAPT (0.52) | MAPTABCC4ALDH1A1LMNAUSP2 | |
| SCHEMBL7644378 | 0.82 | MAPT (0.52) | MAPTABCC4ALDH1A1LMNAUSP2 | |
| SCHEMBL7648294 | 0.82 | MAPT (0.52) | MAPTABCC4ALDH1A1LMNAUSP2 | |
| SCHEMBL7648296 | 0.82 | MAPT (0.52) | MAPTABCC4ALDH1A1LMNAUSP2 | |
| SCHEMBL7647100 | 0.82 | MAPT (0.52) | MAPTABCC4ALDH1A1LMNAUSP2 | |
| SCHEMBL7644371 | 0.82 | MAPT (0.52) | MAPTABCC4ALDH1A1LMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1328498-A1 | METHOD FOR THE CATALYTIC DECOMPOSITION OF LACTONES | BASF AKTIENGESELLSCHAFT (DE) | 2003-07-23 | — | — | EP | disclosed |
| EP-1328498-A1 | METHOD FOR THE CATALYTIC DECOMPOSITION OF LACTONES | BASF AKTIENGESELLSCHAFT (DE) | 2003-07-23 | — | — | EP | disclosed |
| WO-2002016301-A1 | METHOD FOR THE CATALYTIC DECOMPOSITION OF LACTONES | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-28 | — | — | WO | disclosed |
| WO-2002016301-A1 | METHOD FOR THE CATALYTIC DECOMPOSITION OF LACTONES | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-28 | — | — | WO | disclosed |
| EP-0337083-A2 | Process for the preparation of esters of omega enoic acids | HÜLS AKTIENGESELLSCHAFT (DE) | 1989-10-18 | — | — | EP | disclosed |
| EP-0043038-B1 | PROCESS FOR PREPARING MIXTURES OF UNSATURATED C9 CARBOXYLIC ACIDS | EC ERDÖLCHEMIE GMBH (DE) | 1983-06-22 | — | — | EP | disclosed |
| EP-0043038-A1 | Process for preparing mixtures of unsaturated C9 carboxylic acids | EC ERDÖLCHEMIE GMBH (DE) | 1982-01-06 | — | — | EP | disclosed |