Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.38 |
| ▸ | BRD4 | O60885 | 5/20 | 0.38 |
| ▸ | BRD2 | P25440 | 2/20 | 0.38 |
| ▸ | AKT2 | P31751 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7082325 | 1.00 | RET (0.42) | RETPDPK1BRD4BRD2AKT2 | |
| SCHEMBL7091082 | 0.95 | RET (0.38) | RETPDPK1BRD4BRD2AKT2 | |
| SCHEMBL7091081 | 0.95 | RET (0.38) | RETPDPK1BRD4BRD2AKT2 | |
| SCHEMBL7084842 | 0.91 | PDPK1 (0.39) | RETPDPK1BRD4BRD2AKT2 | |
| SCHEMBL7084845 | 0.91 | PDPK1 (0.39) | RETPDPK1BRD4BRD2AKT2 | |
| SCHEMBL7087478 | 0.89 | MAPT (0.46) | NAMPTMEN1LMNAMAPTHTT | |
| SCHEMBL7087474 | 0.89 | MAPT (0.46) | NAMPTMEN1LMNAMAPTHTT | |
| SCHEMBL7243700 | 0.88 | RET (0.45) | RETPDPK1BRD4BRD2AKT2 | |
| SCHEMBL7243698 | 0.88 | RET (0.45) | RETPDPK1BRD4BRD2AKT2 | |
| SCHEMBL7081305 | 0.87 | PDPK1 (0.42) | RETPDPK1BRD4BRD2AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |
| US-6169106-B1 | ANTITUMOUR AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-02 | — | — | US | disclosed |