Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 6/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | TLK2 | Q86UE8 | 4/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7082906 | 1.00 | PDPK1 (0.47) | PDPK1BRD4AKT1AKT2BRD2 | |
| SCHEMBL7086761 | 0.96 | PDPK1 (0.45) | PDPK1BRD4AKT1AKT2BRD2 | |
| SCHEMBL7086762 | 0.96 | PDPK1 (0.45) | PDPK1BRD4AKT1AKT2BRD2 | |
| SCHEMBL29643001 | 0.96 | PDPK1 (0.45) | PDPK1BRD4AKT1AKT2BRD2 | |
| SCHEMBL7089576 | 0.94 | PDPK1 (0.45) | PDPK1BRD4AKT1AKT2BRD2 | |
| SCHEMBL7082439 | 0.94 | PDPK1 (0.45) | PDPK1BRD4AKT1AKT2BRD2 | |
| SCHEMBL7082441 | 0.94 | PDPK1 (0.45) | PDPK1BRD4AKT1AKT2BRD2 | |
| SCHEMBL7848271 | 0.93 | PDPK1 (0.43) | PDPK1BRD4AKT1AKT2BRD2 | |
| SCHEMBL7848267 | 0.93 | PDPK1 (0.43) | PDPK1BRD4AKT1AKT2BRD2 | |
| SCHEMBL7088642 | 0.93 | PDPK1 (0.44) | PDPK1BRD4AKT1AKT2BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |
| US-6169106-B1 | ANTITUMOUR AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-02 | — | — | US | disclosed |