Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 16/20 | 0.81 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7087663 | 0.93 | SERPINE1 (0.89) | SERPINE1NOTUMLMNAMAPTHTT | |
| SCHEMBL7091396 | 0.89 | SERPINE1 (1.00) | SERPINE1NOTUMLMNAMAPTHTT | |
| SCHEMBL7091388 | 0.87 | SERPINE1 (0.68) | SERPINE1NOTUMLMNAMAPTHTT | |
| SCHEMBL7087986 | 0.87 | SERPINE1 (0.77) | SERPINE1LMNAMAPTHTTL3MBTL1 | |
| SCHEMBL7085035 | 0.85 | SERPINE1 (0.68) | SERPINE1NOTUMLMNAMAPTHTT | |
| SCHEMBL7142564 | 0.84 | SERPINE1 (0.66) | SERPINE1NOTUMLMNAMAPTHTT | |
| SCHEMBL4334462 | 0.84 | NOTUM (0.85) | SERPINE1NOTUMLMNAMAPTHTT | |
| SCHEMBL30173256 | 0.84 | NOTUM (0.85) | SERPINE1NOTUMLMNAMAPTHTT | |
| SCHEMBL7088169 | 0.80 | SERPINE1 (1.00) | SERPINE1NOTUMMAPTPOLBCYP2C9 | |
| SCHEMBL7091093 | 0.80 | SERPINE1 (1.00) | SERPINE1NOTUMLMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080060-A1 | SUBSTITUTED PIPERAZINE ANTITHROMBOTIC PAI-1 INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-10-02 | — | — | WO | disclosed |