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SCHEMBL7084873

SCHEMBL7084873

COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCC(O)CN1C(C)C=CC1C.COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCC(O)CN1CCC(C)CC1

nearest known ligand 0.58

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ EGFR P00533 13/20 0.58
▸ FLT1 P17948 17/20 0.58
▸ KDR P35968 17/20 0.58
▸ FGFR1 P11362 16/20 0.58
▸ FLT4 P35916 12/20 0.58
▸ EPHB2 P29323 1/20 0.57
▸ EPHA2 P29317 1/20 0.53
▸ EPHB4 P54760 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5450355 0.95 FLT1 (0.64) EGFRFLT1KDRFGFR1FLT4
Hydrochloric Acid SCHEMBL5453219 0.94 FLT1 (0.65) EGFRFLT1KDRFGFR1FLT4
SCHEMBL5451353 0.93 FLT1 (0.66) EGFRFLT1KDRFGFR1FLT4
Hydrochloric Acid SCHEMBL5452388 0.92 FLT1 (0.65) EGFRFLT1KDRFGFR1FLT4
SCHEMBL5456122 0.89 FLT1 (0.72) EGFRFLT1KDRFGFR1FLT4
Hydrochloric Acid SCHEMBL5446837 0.88 FLT1 (0.71) EGFRFLT1KDRFGFR1FLT4
SCHEMBL14564686 0.88 FLT1 (0.75) EGFRFLT1KDRFGFR1FLT4
SCHEMBL5755914 0.88 FLT1 (0.75) EGFRFLT1KDRFGFR1FLT4
SCHEMBL5465089 0.87 FLT1 (0.73) EGFRFLT1KDRFGFR1FLT4
SCHEMBL5450340 0.87 FLT1 (0.73) EGFRFLT1KDRFGFR1FLT4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1274692-A1 QUINAZOLINE COMPOUNDS AstraZeneca AB (SE) 2003-01-15 — — EP disclosed
WO-2001077085-A1 QUINAZOLINE COMPOUNDS ASTRAZENECA AB (SE) 2001-10-18 — — WO disclosed