Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.44 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6793163 | 0.81 | MAPK14 (0.64) | MAPK14GSK3BMAPK13MAPK12MAPK11 | |
| SCHEMBL6791206 | 0.78 | MAPK14 (0.57) | MAPK14GSK3BMAPK13MAPK12MAPK11 | |
| SCHEMBL6798108 | 0.75 | MAPK14 (0.54) | MAPK14GSK3BMAPK13MAPK12MAPK11 | |
| SCHEMBL6790550 | 0.75 | MAPK14 (0.64) | MAPK14GSK3BMAPK13MAPK12MAPK11 | |
| SCHEMBL6955789 | 0.73 | MAPK14 (0.73) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL7047821 | 0.72 | MAPK14 (0.61) | MAPK14GSK3BMAPK13MAPK12MAPK11 | |
| SCHEMBL6794576 | 0.71 | MAPK14 (0.85) | MAPK14MAPK13MAPK12MAPK11BRD4 | |
| SCHEMBL6791353 | 0.70 | MAPK14 (0.84) | MAPK14MAPK13MAPK12MAPK11BRD4 | |
| SCHEMBL6957344 | 0.70 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11BRD4 | |
| SCHEMBL6795873 | 0.70 | MAPK14 (0.49) | MAPK14GSK3BMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831830-B1 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | disclosed |