Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL11884117 | 0.89 | — | — | |
| Lithium Ion SCHEMBL725902 | 0.80 | — | — | |
| Lithium Ion SCHEMBL3287244 | 0.78 | — | — | |
| SCHEMBL8149153 | 0.78 | — | — | |
| Lithium Ion SCHEMBL8799210 | 0.78 | — | — | |
| Lithium Ion SCHEMBL10681920 | 0.67 | — | — | |
| SCHEMBL8599079 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL7874154 | 0.67 | — | — | |
| Lithium Ion SCHEMBL7397104 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL2582276 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240246909-A1 | EBNA1 Inhibitors and Methods Using Same | WISTAR INST (US) | 2024-07-25 | — | — | US | disclosed |
| US-11912659-B2 | EBNA1 inhibitors and methods using same | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2024-02-27 | — | — | US | disclosed |
| US-20220064112-A1 | EBNA1 Inhibitors and Methods Using Same | WISTAR INST (US) | 2022-03-03 | — | — | US | disclosed |
| US-10981867-B2 | EBNA1 inhibitors and methods using same | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2021-04-20 | — | — | US | disclosed |
| US-20200239415-A1 | EBNA1 INHIBITORS AND METHODS USING SAME | WISTAR INST (US) | 2020-07-30 | — | — | US | disclosed |
| US-10442763-B2 | EBNA1 inhibitors and methods using same | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2019-10-15 | — | — | US | disclosed |
| US-20180305312-A1 | EBNA1 INHIBITORS AND METHODS USING SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-10-25 | — | — | US | disclosed |
| EP-3294705-A1 | EBNA1 INHIBITORS AND METHODS USING SAME | The Wistar Institute Of Anatomy And Biology (US) | 2018-03-21 | — | — | EP | disclosed |
| WO-2016183534-A1 | EBNA1 INHIBITORS AND METHODS USING SAME | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2016-11-17 | — | — | WO | disclosed |
| CN-101466725-B | Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders | SIGMA TAU IND FARMACEUTI | 2014-06-25 | — | — | CN | disclosed |
| CN-101466725-A | Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders | SIGMA TAU IND FARMACEUTI (IT) | 2009-06-24 | — | — | CN | disclosed |
| EP-1189925-B1 | NEW PROCESS FOR THE SYNTHESIS OF 17BETA-HYDROXY-17ALPHA-METHYL-2-OXA-5ALPHA-ANDROSTANE-3-ONE | RICHTER GEDEON VEGYESZET (HU) | 2003-07-23 | — | — | EP | disclosed |
| US-6583298-B1 | Ring closure and reduction of 17-hydroxy-17-methyl-1,3-seco-2-nor-5-androstane-1,3-diacid without intermediate separation | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2003-06-24 | — | — | US | disclosed |
| EP-1189925-A1 | NEW PROCESS FOR THE SYNTHESIS OF 17BETA-HYDROXY-17ALPHA-METHYL-2-OXA-5ALPHA-ANDROSTANE-3-ONE | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000077025-A1 | NEW PROCESS FOR THE SYNTHESIS OF 17β-HYDROXY-17α-METHYL-2-OXA-5α-ANDROSTANE-3-ONE | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2000-12-21 | — | — | WO | disclosed |
| US-5137889-A | Hypotensive agents; coronary vasodilators; calcium antagonists; antiinflammatory agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-08-11 | — | — | US | disclosed |
| US-5034395-A | Hypotensive agents, carboxylated dihydropyridines | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-23 | — | — | US | disclosed |
| EP-0145434-A2 | Novel dihydropyridine derivatives and process for preparing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-19 | — | — | EP | disclosed |