Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.50 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CRHBP | P24387 | 2/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3267497 | 0.67 | MAP3K14 (0.64) | MAP3K14ITGB2ICAM1ITGALLMNA | |
| SCHEMBL3559500 | 0.67 | MAP3K14 (1.00) | MAP3K14ITGB2ICAM1ITGALLMNA | |
| SCHEMBL136087 | 0.67 | MAP3K14 (0.46) | MAP3K14ITGB2ICAM1ITGALLMNA | |
| SCHEMBL30216657 | 0.66 | MAP3K14 (0.45) | MAP3K14ITGB2ICAM1ITGALLMNA | |
| SCHEMBL4729948 | 0.66 | MAP3K14 (0.67) | MAP3K14ITGB2ICAM1ITGALLMNA | |
| SCHEMBL10365755 | 0.66 | MAP3K14 (0.45) | MAP3K14ITGB2ICAM1ITGALLMNA | |
| SCHEMBL3561436 | 0.66 | MAP3K14 (0.67) | MAP3K14ITGB2ICAM1ITGALLMNA | |
| SCHEMBL31300318 | 0.66 | MAP3K14 (0.45) | MAP3K14ITGB2ICAM1ITGALLMNA | |
| SCHEMBL1266237 | 0.66 | MAP3K14 (0.45) | MAP3K14ITGB2ICAM1ITGALLMNA | |
| SCHEMBL9900378 | 0.66 | MAP3K14 (0.53) | MAP3K14ITGB2ICAM1ITGALLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1204134-C | Sulfamine-substituted benzodihydopyran, preparation method, use as medicine or diagnostic reagent and medicine containing same | HOECHST AG (DE) | 2005-06-01 | — | — | CN | disclosed |
| EP-1228058-A4 | BENZOPYRANYL GUANIDINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DONGBU HANNONG CHEMICAL CO LTD (KR) | 2003-02-12 | — | — | EP | disclosed |
| EP-1228058-A1 | BENZOPYRANYL GUANIDINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dongbu Hannong Chemical Co., Ltd. (KR) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001029023-A1 | BENZOPYRANYL GUANIDINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2001-04-26 | — | — | WO | disclosed |
| CN-1218050-A | Sulfonamide-substituted benzopyran derivates processes for their preparation, their use as medicament, and pharmaceutical preparations comprising them | HOECHST MARION ROUSSEL DE GMBH (DE) | 1999-06-02 | — | — | CN | disclosed |
| CN-1194982-A | Sulfonamide-substituted chromans, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them | HOECHST AG (DE) | 1998-10-07 | — | — | CN | disclosed |
| CN-1169429-A | Sulfamine-substituted benzodihydopyran, preparation method, use as medicine or diagnostic reagent and medicine containing same | HOECHST AG (DE) | 1998-01-07 | — | — | CN | disclosed |