Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | FPR3 | P25089 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6150181 | 0.87 | KDM4E (0.58) | KDM4EPKMALDH1A1NPC1MAPT | |
| SCHEMBL3098100 | 0.83 | KDM4E (0.62) | KDM4EPKMGPR119EPHX1FPR3 | |
| SCHEMBL7754715 | 0.82 | KDM4E (0.59) | KDM4EPKMALDH1A1GPR119EPHX1 | |
| SCHEMBL6157052 | 0.82 | KDM4E (0.56) | KDM4EPKMGPR119EPHX1FPR3 | |
| SCHEMBL19652088 | 0.82 | KDM4E (0.60) | KDM4EPKMALDH1A1NPC1MAPT | |
| SCHEMBL3050761 | 0.82 | KDM4E (0.60) | KDM4EPKMGPR119EPHX1FPR3 | |
| SCHEMBL31117959 | 0.82 | KDM4E (0.60) | KDM4EPKMGPR119EPHX1FPR3 | |
| SCHEMBL104607 | 0.81 | HPGD (0.50) | KDM4EPKMALDH1A1NPC1MAPT | |
| SCHEMBL6402066 | 0.81 | KDM4E (0.59) | KDM4EPKMGPR119EPHX1FPR3 | |
| SCHEMBL24853346 | 0.80 | KDM4E (0.64) | KDM4EPKMEPHX1FPR3FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341755-A1 | CARBOXYLIC ACID AMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF THROMBOEMBOLIC DISEASES AND TUMOURS | MERCK PATENT GmbH (DE) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002048099-A1 | CARBOXYLIC ACID AMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF THROMBOEMBOLIC DISEASES AND TUMOURS | MERCK PATENT GMBH (DE) | 2002-06-20 | — | — | WO | disclosed |