Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6494687 | 0.94 | HDAC8 (0.44) | HDAC8ALDH1A1HPSEHDAC1HDAC6 | |
| SCHEMBL6493899 | 0.82 | MAPT (0.47) | ALDH1A1SMN1; SMN2KDM4ELMNAMAPT | |
| SCHEMBL6492806 | 0.80 | KMT2A (0.40) | SMN1; SMN2KDM4ELMNAMAPTHPGD | |
| Hydrochloric Acid SCHEMBL6493224 | 0.79 | KMT2A (0.39) | SMN1; SMN2KDM4EMAPTHPGDKMT2A | |
| SCHEMBL6493106 | 0.79 | MAPT (0.54) | ALDH1A1SMN1; SMN2KDM4ELMNAMAPT | |
| SCHEMBL6496748 | 0.78 | PI4KB (0.42) | ALDH1A1SMN1; SMN2KDM4ELMNAMAPT | |
| SCHEMBL7073827 | 0.78 | MAPT (0.41) | ALDH1A1HPSESMN1; SMN2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL7073825 | 0.77 | MAPT (0.41) | ALDH1A1HPSESMN1; SMN2KDM4ELMNA | |
| SCHEMBL6496194 | 0.77 | MAPT (0.43) | HDAC8ALDH1A1HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL6503258 | 0.75 | ABCB1 (0.46) | ALDH1A1SMN1; SMN2KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294686-A2 | INDOLE DERIVATIVES AND THEIR USE AS 15-LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001096299-A2 | INDOLE DERIVATIVES AND THEIR USE AS 15-LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |