Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL11444291 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL11827822 | 0.79 | — | — | |
| Bromide SCHEMBL28720792 | 0.72 | — | — | |
| SCHEMBL322046 | 0.70 | — | — | |
| Bromide SCHEMBL28720794 | 0.69 | — | — | |
| SCHEMBL28539808 | 0.67 | — | — | |
| Bromide SCHEMBL8596483 | 0.64 | — | — | |
| SCHEMBL5161618 | 0.63 | CA12 (0.39) | — | |
| Bromide SCHEMBL28722724 | 0.62 | — | — | |
| SCHEMBL11198442 | 0.60 | TDP1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610715-B1 | Inhibit the enzymatic activity of phosphodiesterase IV or tumor necrosis factor | CHEIL JEDANG CORPORATION (KR) | 2003-08-26 | — | — | US | disclosed |
| EP-1187817-B1 | CATHECOL HYDRAZONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | CHEIL JEDANG CORP (KR) | 2003-07-30 | — | — | EP | disclosed |
| EP-1187817-A1 | CATHECOL HYDRAZONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Cheil Jedang Corporation (KR) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000073280-A1 | CATHECOL HYDRAZONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | CHEIL JEDANG CORPORATION (KR) | 2000-12-07 | — | — | WO | disclosed |
| US-5185247-A | Qualitative or quantitative analysis of glucose, cholesterol, uric acid or lower alcohols in a fluid sample by contacting with a reagent containing an oxidase, an oxidizable chromogen, peroxidase, a buffer and a hydarzine for colorimetric analysis | MILES INC. (US) | 1993-02-09 | — | — | US | disclosed |
| EP-0386562-A2 | Stabilization of oxidase enzyme-based test strips | Bayer Corporation (US) | 1990-09-12 | — | — | EP | disclosed |
| US-4665085-A | GLAUCOMA | LABORATOIRES CHAUVIN-BLACHE (FR) | 1987-05-12 | — | — | US | disclosed |
| US-4109008-A | SUBSTITUTED WITH AN AMIDINO AND A 1,3-DIMETHYL-2-OXO-BENZIMIDAZOL- 5-YL RADICAL | HEXACHIMIE (FR) | 1978-08-22 | — | — | US | disclosed |
| US-3931152-A | ANTITUBERCULAR | AMERICAN CYANAMID COMPANY (US) | 1976-01-06 | — | — | US | disclosed |