Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | PIK3R2 | O00459 | 4/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | F7 | P08709 | 2/20 | 0.35 |
| ▸ | F3 | P13726 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5848346 | 0.75 | F7 (0.53) | F2F7F3 | |
| SCHEMBL15813339 | 0.65 | PIK3CD (0.65) | PIK3CDPIK3R1PIK3R2 | |
| SCHEMBL15818373 | 0.64 | PIK3CD (0.59) | PIK3CDPIK3R1PIK3R2 | |
| SCHEMBL3833549 | 0.62 | NOTUM (0.53) | MAT2ANOTUMCXCR3ALDH1A1TP53 | |
| SCHEMBL14726605 | 0.62 | PIK3CD (0.49) | MAT2APIK3CDPIK3R1NPBWR1MCHR1 | |
| SCHEMBL5846898 | 0.61 | F7 (0.68) | F2F7F3 | |
| SCHEMBL15812549 | 0.61 | PIK3CD (0.51) | PIK3CDPIK3R1CXCR3 | |
| SCHEMBL15819283 | 0.61 | PIK3CD (0.48) | PIK3CDPIK3R1PIK3R2 | |
| SCHEMBL15812448 | 0.61 | PIK3CD (0.66) | PIK3CDPIK3R1PIK3R2 | |
| SCHEMBL15812450 | 0.61 | PIK3CD (0.66) | PIK3CDPIK3R1PIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292579-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001087854-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-11-22 | — | — | WO | disclosed |