Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 14/20 | 0.74 |
| ▸ | CTSB | P07858 | 4/20 | 0.74 |
| ▸ | CTSL | P07711 | 4/20 | 0.74 |
| ▸ | CTSK | P43235 | 2/20 | 0.74 |
| ▸ | CAPN9 | O14815 | 2/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | CTSH | P09668 | 1/20 | 0.74 |
| ▸ | CTSS | P25774 | 1/20 | 0.74 |
| ▸ | CTSC | P53634 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | USP2 | O75604 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | BLM | P54132 | 1/20 | 0.74 |
| ▸ | CTSG | P08311 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| E-64 SCHEMBL13283063 | 1.00 | CAPN1 (0.74) | CAPN1CTSBCTSLCTSKCAPN9 | |
| E-64 SCHEMBL23132676 | 1.00 | CAPN1 (0.74) | CAPN1CTSBCTSLCTSKCAPN9 | |
| E-64 SCHEMBL4740187 | 1.00 | CAPN1 (0.74) | CAPN1CTSBCTSLCTSKCAPN9 | |
| E-64 SCHEMBL13523481 | 1.00 | CAPN1 (0.74) | CAPN1CTSBCTSLCTSKCAPN9 | |
| E-64 SCHEMBL16452857 | 1.00 | CAPN1 (0.74) | CAPN1CTSBCTSLCTSKCAPN9 | |
| E-64 SCHEMBL32663599 | 0.99 | CAPN1 (0.73) | CAPN1CTSBCTSLCTSKCAPN9 | |
| SCHEMBL11067480 | 0.88 | CAPN1 (0.74) | CAPN1CTSBCTSLCTSKCAPN9 | |
| Agmatine SCHEMBL18784085 | 0.88 | CAPN1 (0.59) | CAPN1CTSBCTSLCTSKCAPN9 | |
| SCHEMBL11184932 | 0.87 | CAPN1 (0.72) | CAPN1CTSBCTSLCTSKCAPN9 | |
| SCHEMBL11188762 | 0.87 | CAPN1 (0.72) | CAPN1CTSBCTSLCTSKCAPN9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6551999-B1 | For therapy and prophylaxis of angiogenesis associated with wound healing, inflammation, growth of tumor and the like; angiogenesis as seen in diabetic retinopathy, prematurity retinopathy, retinal venous occlusion, metastasis of tumors | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2003-04-22 | — | — | US | disclosed |
| EP-0771565-B1 | Angiogenesis inhibitor | SENJU PHARMA CO (JP) | 2003-01-02 | — | — | EP | disclosed |
| US-6214800-B1 | ANGIOGENESIS INHIBITORS | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2001-04-10 | — | — | US | disclosed |
| US-6057290-A | ADMINISTERING A CYSTEINE PROTEASE INHIBITOR TO A PATIENT FOR INHIBITING ANGIOGENESIS | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2000-05-02 | — | — | US | disclosed |
| EP-0928786-A1 | Angiogenesis inhibitor | Senju Pharmaceutical Co., Ltd. (JP) | 1999-07-14 | — | — | EP | disclosed |
| EP-0927716-A1 | Angiogenesis inhibitor | Senju Pharmaceutical Co., Ltd. (JP) | 1999-07-07 | — | — | EP | disclosed |
| EP-0771565-A2 | Angiogenesis inhibitor | Senju Pharmaceutical Co., Ltd. (JP) | 1997-05-07 | — | — | EP | disclosed |