SCHEMBL7087344

SCHEMBL7087344

Cn1cncc1C(NCc1ccc(S(C)(=O)=O)cc1)c1ccc(C#N)c(-c2cccc3ccccc23)c1

nearest known ligand 0.58

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PGGT1B P53609 3/20 0.58
FNTA P49354 3/20 0.58
FNTB P49356 3/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7600698 0.99 PGGT1B (0.57) PGGT1BFNTAFNTB
SCHEMBL7086303 0.90 FNTA (0.71) PGGT1BFNTAFNTB
Hydrochloric Acid SCHEMBL7087288 0.89 FNTA (0.70) PGGT1BFNTAFNTB
SCHEMBL7092629 0.89 FNTA (0.61) PGGT1BFNTAFNTB
SCHEMBL7088755 0.88 PGGT1B (0.58) PGGT1BFNTAFNTB
Lithium Ion SCHEMBL7572151 0.88 PGGT1B (0.56) PGGT1BFNTAFNTB
SCHEMBL7572159 0.88 PGGT1B (0.58) PGGT1BFNTAFNTB
SCHEMBL7090343 0.87 PGGT1B (0.61) PGGT1BFNTAFNTB
SCHEMBL7090226 0.87 PGGT1B (0.57) PGGT1BFNTAFNTB
SCHEMBL6983406 0.86 FNTA (0.60) PGGT1BFNTAFNTB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1276726-A2 SUBSTITUTED PHENYL FARNESYLTRANSFERASE INHIBITORS Abbott Laboratories (US) 2003-01-22 EP disclosed
WO-2001081316-A2 SUBSTITUTED PHENYL FARNESYLTRANSFERASE INHIBITORS ABBOTT LABORATORIES (US) 2001-11-01 WO disclosed