Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.56 |
| ▸ | LTA4H | P09960 | 6/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | REN | P00797 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PEPD | P12955 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29290359 | 1.00 | ACE (0.56) | ACELTA4HACE2LMNAKDM4E | |
| Trifluoroacetic Acid SCHEMBL29290367 | 0.94 | ACE (0.53) | ACELTA4HACE2 | |
| SCHEMBL12253518 | 0.85 | ACE (0.52) | ACELTA4HACE2LMNA | |
| SCHEMBL27890164 | 0.84 | ACE (0.73) | ACELTA4HACE2LMNAF2 | |
| SCHEMBL27890165 | 0.84 | ACE (0.73) | ACELTA4HACE2LMNAF2 | |
| SCHEMBL6436563 | 0.83 | ACE (0.65) | ACELTA4HACE2LMNA | |
| SCHEMBL6438293 | 0.83 | ACE (0.65) | ACELTA4HACE2LMNA | |
| SCHEMBL6436560 | 0.83 | ACE (0.65) | ACELTA4HACE2LMNA | |
| SCHEMBL6438290 | 0.83 | ACE (0.65) | ACELTA4HACE2LMNA | |
| SCHEMBL31197026 | 0.82 | ACE (0.67) | ACELTA4HACE2LMNAREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003075901-A2 | USE OF S-SUBSTITUTED L-CRYSTEINE FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF DERMATOLOGICAL DISORDERS | GHISALBERTI CARLO (BR) | 2003-09-18 | — | — | WO | disclosed |
| US-4472380-A | CARBOXYALKYL DIPEPTIDE DERIVATIVES | MERCK & CO., INC. (US) | 1984-09-18 | — | — | US | disclosed |
| US-4374829-A | Aminoacid derivatives as antihypertensives | MERCK & CO., INC. (US) | 1983-02-22 | — | — | US | disclosed |
| EP-0012401-A1 | Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1980-06-25 | — | — | EP | disclosed |