Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 8/20 | 0.55 |
| ▸ | LTA4H | P09960 | 5/20 | 0.52 |
| ▸ | DPP4 | P27487 | 2/20 | 0.50 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.50 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.50 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.50 |
| ▸ | FAP | Q12884 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11545273 | 0.86 | ACE (0.57) | ACELTA4H | |
| SCHEMBL4330942 | 0.84 | ACE (0.70) | ACELTA4HDPP4DPP8DPP9 | |
| SCHEMBL5900809 | 0.84 | ACE (0.70) | ACELTA4HDPP4DPP8DPP9 | |
| SCHEMBL6436643 | 0.84 | ACE (0.70) | ACELTA4HDPP4DPP8DPP9 | |
| SCHEMBL3726264 | 0.84 | ACE (0.70) | ACELTA4HDPP4DPP8DPP9 | |
| SCHEMBL29666849 | 0.84 | ACE (0.70) | ACELTA4HDPP4DPP8DPP9 | |
| SCHEMBL31026624 | 0.84 | ACE (0.70) | ACELTA4HDPP4DPP8DPP9 | |
| SCHEMBL7375090 | 0.84 | ACE (0.70) | ACELTA4HDPP4DPP8DPP9 | |
| SCHEMBL3726263 | 0.84 | ACE (0.70) | ACELTA4HDPP4DPP8DPP9 | |
| SCHEMBL6373910 | 0.83 | ACE (0.69) | ACELTA4HDPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003075901-A2 | USE OF S-SUBSTITUTED L-CRYSTEINE FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF DERMATOLOGICAL DISORDERS | GHISALBERTI CARLO (BR) | 2003-09-18 | — | — | WO | disclosed |
| US-4472380-A | CARBOXYALKYL DIPEPTIDE DERIVATIVES | MERCK & CO., INC. (US) | 1984-09-18 | — | — | US | disclosed |
| US-4374829-A | Aminoacid derivatives as antihypertensives | MERCK & CO., INC. (US) | 1983-02-22 | — | — | US | disclosed |
| EP-0012401-A1 | Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1980-06-25 | — | — | EP | disclosed |