Acetic Acid

Acetic Acid

SCHEMBL7087942

CC(=O)O.CCCCCCl

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 known ✓ P03372 1/20 0.46
TSHR P16473 7/20 0.63
ALDH1A1 P00352 4/20 0.63
TDP1 Q9NUW8 3/20 0.53
AKR1B1 P15121 1/20 0.48
FAAH O00519 2/20 0.47
GPR84 Q9NQS5 7/20 0.46
PPARG P37231 7/20 0.46
PPARD Q03181 7/20 0.46
PPARA Q07869 7/20 0.46
HDAC11 Q96DB2 5/20 0.46
PTPN1 P18031 3/20 0.46
TLR2 O60603 2/20 0.46
FABP4 P15090 2/20 0.46
SLC22A6 Q4U2R8 1/20 0.46
SLC22A8 Q8TCC7 1/20 0.46
MEN1 O00255 1/20 0.46
ALOX15 P16050 1/20 0.46
PDE4A P27815 1/20 0.46
KMT2A Q03164 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL28178945 0.97 TSHR (0.68) TSHRALDH1A1TDP1AKR1B1FAAH
Butyl Chloride SCHEMBL9830095 0.92
Butyl Chloride SCHEMBL14719151 0.92 TSHR (0.65) TSHRALDH1A1TDP1AKR1B1FAAH
Acetone SCHEMBL27529878 0.92 TSHR (0.67) TSHRALDH1A1TDP1AKR1B1FAAH
Bicarbonate SCHEMBL38662423 0.92 TSHR (0.67) TSHRALDH1A1TDP1AKR1B1FAAH
Acetic Acid SCHEMBL29024963 0.91 TSHR (0.52) TSHRALDH1A1TDP1AKR1B1FAAH
Pyruvate SCHEMBL27923180 0.90 TSHR (0.57) TSHRALDH1A1TDP1AKR1B1FAAH
Butyl Chloride SCHEMBL7820081 0.89 TSHR (0.61) TSHRALDH1A1TDP1AKR1B1FAAH
Bicarbonate SCHEMBL8772568 0.89 TSHR (0.72) TSHRALDH1A1TDP1AKR1B1FAAH
Bicarbonate SCHEMBL6052976 0.89 TSHR (0.72) TSHRALDH1A1TDP1AKR1B1FAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107721968-A Indeno fused ring compound 光学转变公司 2018-02-23 CN disclosed
CN-104163792-B N-picolinamide compound, preparation method and application thereof 湖南化工研究院 2017-04-12 CN disclosed
CN-103328462-A Indeno-fused ring compounds TRANSITIONS OPTICAL INC 2013-09-25 CN disclosed
CN-1216046-C Improved methods of synthesis for 9-substituted hypoxanthine derivatives MORK EPROWA AG (CH) 2005-08-24 CN disclosed
CN-1166723-C Polystyrene sulfonate film for low-temp. direct methanol fuel cell and preparation process thereof 华南理工大学 2004-09-15 CN disclosed
CN-1449387-A Improved methods of synthesis for 9-substituted hypoxanthine derivatives NEOTHERAPEUTICS INC (US) 2003-10-15 CN disclosed
EP-0799218-B1 DIARYL-2-(5H)-FURANONES AS COX-2 INHIBITORS MERCK FROSST CANADA INC (CA) 2003-02-19 EP disclosed
CN-1385459-A Polystyrene sulfonate film for low-temp. direct methanol fuel cell and preparation process thereof HUA NAN SCIENCE AND ENGINEERIN (CN) 2002-12-18 CN disclosed
CN-1095748-C Aromatic polyamide film and magnetic recording media made by using same TORAY INDUSTRIES (JP) 2002-12-11 CN disclosed
US-6222048-B1 AS ANTIINFLAMMATORY, ANTIPYRETIC AND ANALGESIC AGENTS; INHIBITS HORMONE INDUCED UTERINE CONTRACTION; ANTICANCER PROPERTIES; SIDE EFFECT REDUCTION MERCK FROSST CANADA & CO. (CA) 2001-04-24 US disclosed
CN-1242739-A Aromatic polyamide film and magnetic recording media made by using same TORAY INDUSTRIES (JP) 2000-01-26 CN disclosed
US-5939419-A HYPOTENSIVE AGENTS AND BRONCHODILATOR AGENTS SCHERING-PLOUGH CORPORATION (US) 1999-08-17 US disclosed
EP-0799218-A1 DIARYL-2-(5H)-FURANONES AS COX-2 INHIBITORS MERCK FROSST CANADA INC. (CA) 1997-10-08 EP disclosed
WO-1996019469-A1 DIARYL-2-(5H)-FURANONES AS COX-2 INHIBITORS MERCK FROSST CANADA INC. (CA) 1996-06-27 WO disclosed
EP-0686157-A1 2-BENZYL-POLYCYCLIC GUANINE DERIVATIVES AND PROCESS FOR PREPARING THEM SCHERING CORPORATION (US) 1995-12-13 EP disclosed
WO-1994019351-A1 2-BENZYL-POLYCYCLIC GUANINE DERIVATIVES AND PROCESS FOR PREPARING THEM SCHERING CORPORATION (US) 1994-09-01 WO disclosed
EP-0236628-B1 INHIBITION OF THE 5-LIPOXYGENASE PATHWAY SMITHKLINE BEECHAM CORPORATION (US) 1992-12-02 EP disclosed
CN-1053919-A New imidazolium compounds, its preparation method and based on medicament and some intermediate product of these compounds HOECHST AG (DE) 1991-08-21 CN disclosed
EP-0236628-A1 Inhibition of the 5-lipoxygenase pathway SMITHKLINE BEECHAM CORPORATION (US) 1987-09-16 EP disclosed