Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7087999 | 1.00 | MEN1 (0.43) | MEN1HTTKMT2ASMN1; SMN2MAPT | |
| SCHEMBL6326418 | 0.89 | IDO1 (0.52) | MEN1HTTKMT2ASMN1; SMN2MAPT | |
| SCHEMBL6326423 | 0.89 | IDO1 (0.52) | MEN1HTTKMT2ASMN1; SMN2MAPT | |
| SCHEMBL7087804 | 0.86 | PDPK1 (0.42) | MEN1HTTKMT2ASMN1; SMN2MAPT | |
| SCHEMBL7087806 | 0.86 | PDPK1 (0.42) | MEN1HTTKMT2ASMN1; SMN2MAPT | |
| SCHEMBL5783077 | 0.85 | RET (0.48) | MEN1HTTKMT2ASMN1; SMN2MAPT | |
| SCHEMBL7474780 | 0.85 | RET (0.48) | MEN1HTTKMT2ASMN1; SMN2MAPT | |
| SCHEMBL5783080 | 0.85 | RET (0.48) | MEN1HTTKMT2ASMN1; SMN2MAPT | |
| SCHEMBL5627554 | 0.85 | AURKA (0.47) | MEN1HTTKMT2ASMN1; SMN2MAPT | |
| SCHEMBL6986615 | 0.85 | AURKA (0.47) | MEN1HTTKMT2ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |
| US-6169106-B1 | ANTITUMOUR AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-02 | — | — | US | disclosed |