Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.78 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.78 |
| ▸ | CDK9 | P50750 | 10/20 | 0.78 |
| ▸ | CDK1 | P06493 | 8/20 | 0.78 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.78 |
| ▸ | CDK4 | P11802 | 7/20 | 0.78 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.78 |
| ▸ | CDK7 | P50613 | 7/20 | 0.78 |
| ▸ | CCNH | P51946 | 7/20 | 0.78 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.78 |
| ▸ | ABL1 | P00519 | 4/20 | 0.62 |
| ▸ | AURKA | O14965 | 1/20 | 0.62 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.62 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.62 |
| ▸ | CCND1 | P24385 | 1/20 | 0.62 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.62 |
| ▸ | ABL2 | P42684 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 1/20 | 0.62 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.62 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2282051 | 0.87 | CDK2 (1.00) | CDK2CCNT1CDK9CDK1CCNB1 | |
| SCHEMBL6684173 | 0.86 | CDK2 (0.63) | CDK2CCNT1CDK9CDK1CCNB1 | |
| SCHEMBL1807318 | 0.82 | CDK2 (0.79) | CDK2CCNT1CDK9CDK1CCNB1 | |
| SCHEMBL6156443 | 0.78 | CDK2 (1.00) | CDK2CCNT1CDK9CDK1CCNB1 | |
| SCHEMBL29354713 | 0.78 | CDK2 (1.00) | CDK2CCNT1CDK9CDK1CCNB1 | |
| SCHEMBL4167919 | 0.78 | CDK2 (0.82) | CDK2CCNT1CDK9CDK1CCNB1 | |
| SCHEMBL20817070 | 0.78 | CDK2 (0.79) | CDK2CCNT1CDK9CDK1CCNB1 | |
| SCHEMBL2086977 | 0.78 | CDK2 (0.73) | CDK2CCNT1CDK9CDK1CCNB1 | |
| SCHEMBL4795797 | 0.77 | CDK2 (0.81) | CDK2CCNT1CDK9CDK1CCNB1 | |
| SCHEMBL4386032 | 0.77 | CDK2 (0.72) | CDK2CCNT1CDK9CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1274705-A1 | 2-SUBSTITUTED 4-HETEROARYL-PYRIMIDINES AND THEIR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | Cyclacel Limited (GB) | 2003-01-15 | — | — | EP | disclosed |
| WO-2001072745-A1 | 2-SUBSTITUTED 4-HETEROARYL-PYRIMIDINES AND THEIR USE IN THE TREATMETN OF PROLIFERATIVE DISORDERS | CYCLACEL LIMITED (GB) | 2001-10-04 | — | — | WO | disclosed |