Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HRH2 | P25021 | 6/20 | 0.49 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5346308 | 0.93 | HRH2 (0.53) | HSD17B10SMN1; SMN2HRH2BRD4MEN1 | |
| SCHEMBL5344746 | 0.87 | HRH2 (0.60) | HSD17B10SMN1; SMN2HRH2BRD4MEN1 | |
| SCHEMBL5341750 | 0.83 | HRH2 (0.63) | HSD17B10SMN1; SMN2HRH2BRD4MEN1 | |
| SCHEMBL5342917 | 0.78 | HTR2A (0.53) | HSD17B10SMN1; SMN2HRH2KDM4EALDH1A1 | |
| SCHEMBL5345919 | 0.78 | CYP1A2 (0.46) | SMN1; SMN2HRH2KDM4EALDH1A1NOS1 | |
| SCHEMBL5357911 | 0.77 | TSHR (0.54) | HSD17B10HRH2MEN1KMT2AKDM4E | |
| SCHEMBL5350384 | 0.75 | HTR2A (0.57) | HSD17B10SMN1; SMN2HRH2KDM4EALDH1A1 | |
| SCHEMBL5345507 | 0.75 | HRH2 (0.64) | HRH2 | |
| SCHEMBL5349323 | 0.74 | HRH2 (0.65) | HRH2 | |
| SCHEMBL5358649 | 0.74 | HRH2 (0.48) | HRH2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1330453-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | Almirall Prodesfarma, S.A. (ES) | 2003-07-30 | — | — | EP | disclosed |
| WO-2002036589-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA S.A. (ES) | 2002-05-10 | — | — | WO | disclosed |