Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 11/20 | 0.68 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7087794 | 0.96 | TACR1 (0.62) | TACR1P2RY14MAPTMEN1KMT2A | |
| SCHEMBL7090456 | 0.95 | TACR1 (0.61) | TACR1P2RY14MAPTMEN1KMT2A | |
| SCHEMBL7091686 | 0.95 | TACR1 (0.69) | TACR1P2RY14MAPTMEN1KMT2A | |
| SCHEMBL7084238 | 0.94 | TACR1 (0.63) | TACR1P2RY14MAPTMEN1KMT2A | |
| SCHEMBL7082671 | 0.94 | TACR1 (0.60) | TACR1P2RY14MAPTMEN1KMT2A | |
| SCHEMBL7088635 | 0.94 | TACR1 (0.61) | TACR1P2RY14MAPTMEN1KMT2A | |
| SCHEMBL7088838 | 0.94 | MEN1 (0.61) | TACR1P2RY14MAPTMEN1KMT2A | |
| SCHEMBL7088170 | 0.94 | TACR1 (0.69) | TACR1P2RY14MAPTMEN1KMT2A | |
| SCHEMBL7089015 | 0.94 | TACR1 (0.70) | TACR1P2RY14MAPTMEN1KMT2A | |
| SCHEMBL7081275 | 0.93 | TACR1 (0.59) | TACR1P2RY14MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005454-A4 | 2-ACYLAMINOPROPANAMINES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2003-01-15 | — | — | EP | disclosed |
| US-6358994-B1 | 2-((2-PHENOXY)ACETYL)AMINO-3-(1H-INDOL-3-YL)-1-(N-2 -METHOXYBENZYL)ACETYLAMINO)PROPANE | ELI LILLY AND COMPANY | 2002-03-19 | — | — | US | disclosed |
| EP-1005454-A1 | 2-ACYLAMINOPROPANAMINES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-06-07 | — | — | EP | disclosed |
| WO-1999007677-A1 | 2-ACYLAMINOPROPANAMINES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1999-02-18 | — | — | WO | disclosed |