Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983794 | 0.90 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL7455807 | 0.88 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL5142292 | 0.87 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL5142289 | 0.87 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL5142291 | 0.87 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL7518155 | 0.85 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL7091963 | 0.85 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL27514351 | 0.84 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4026130 | 0.81 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4025297 | 0.80 | PDE4A (0.87) | PDE4APDE4BPDE4CPDE4DCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363635-A1 | SUBSTITUTED 8-ARYLQUINOLINE PHOSPHODIESTERASE-4 INHIBITORS | Merck & Co., Inc. (US) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002069970-A1 | SUBSTITUTED 8-ARYLQUINOLINE PHOSPHODIESTERASE-4 INHIBITORS | MERCK & CO., INC. (US) | 2002-09-12 | — | — | WO | disclosed |