Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047768 | 0.85 | FLT3 (0.64) | FLT3LMNASMN1; SMN2GLAL3MBTL1 | |
| SCHEMBL12779064 | 0.77 | FLT3 (0.55) | FLT3LMNASMN1; SMN2GLAL3MBTL1 | |
| SCHEMBL4036342 | 0.75 | FLT3 (0.66) | FLT3LMNASMN1; SMN2GLAL3MBTL1 | |
| SCHEMBL1248063 | 0.75 | FLT3 (0.53) | FLT3LMNASMN1; SMN2GLAL3MBTL1 | |
| SCHEMBL4039312 | 0.74 | FLT3 (0.62) | FLT3LMNASMN1; SMN2GLAL3MBTL1 | |
| SCHEMBL12779226 | 0.73 | FLT3 (0.60) | FLT3LMNASMN1; SMN2GLAL3MBTL1 | |
| SCHEMBL4039213 | 0.73 | FLT3 (0.64) | FLT3LMNASMN1; SMN2ALDH1A1CA12 | |
| SCHEMBL4043648 | 0.72 | FLT3 (0.60) | FLT3LMNASMN1; SMN2GLAL3MBTL1 | |
| SCHEMBL4038418 | 0.71 | FLT3 (0.65) | FLT3LMNASMN1; SMN2ALDH1A1CA1 | |
| SCHEMBL4036045 | 0.71 | FLT3 (0.58) | FLT3LMNASMN1; SMN2GLAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355889-A1 | SUBSTITUTED TRIAZOLE DIAMINE DERIVATIVES AS KINASE INHIBITORS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002057240-A1 | SUBSTITUTED TRIAZOLE DIAMINE DERIVATIVES AS KINASE INHIBITORS | ORTHO MC NEIL PHARMACEUTICAL, INC. (US) | 2002-07-25 | — | — | WO | disclosed |