Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7090735 | 0.92 | MAPT (0.58) | MAPTTP53SMN1; SMN2KDM4EHTT | |
| SCHEMBL7087515 | 0.87 | MAPT (0.48) | MAPTTP53SMN1; SMN2KDM4EHTT | |
| SCHEMBL7091279 | 0.87 | MAPT (0.48) | MAPTTP53SMN1; SMN2KDM4EHTT | |
| SCHEMBL6523435 | 0.86 | MAPT (0.48) | MAPTTP53SMN1; SMN2KDM4EHTT | |
| SCHEMBL6512358 | 0.85 | MAPT (0.47) | MAPTTP53SMN1; SMN2KDM4EHTT | |
| SCHEMBL6520632 | 0.84 | MAPT (0.47) | MAPTTP53SMN1; SMN2KDM4EHTT | |
| SCHEMBL6512258 | 0.84 | MAPT (0.47) | MAPTTP53SMN1; SMN2KDM4EHTT | |
| SCHEMBL6512262 | 0.84 | MAPT (0.47) | MAPTTP53SMN1; SMN2KDM4EHTT | |
| SCHEMBL6514151 | 0.84 | MAPT (0.47) | MAPTTP53SMN1; SMN2KDM4EHTT | |
| SCHEMBL7088514 | 0.84 | MAPT (0.56) | MAPTTP53SMN1; SMN2KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347959-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | Bayer Aktiengesellschaft (DE) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051805-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | disclosed |