Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 3/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7090864 | 0.90 | MAPT (0.60) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL7085558 | 0.88 | MAPT (0.47) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL7093569 | 0.88 | MAPT (0.49) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL7093571 | 0.87 | MAPT (0.53) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL7088502 | 0.84 | MAPT (0.43) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL7092489 | 0.82 | MAPT (0.54) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL7092492 | 0.81 | MAPT (0.53) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL7090124 | 0.80 | MAPT (0.48) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL7089088 | 0.79 | MAPT (0.47) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL7088467 | 0.79 | MAPT (0.47) | MAPTSMN1; SMN2HTTLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347959-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | Bayer Aktiengesellschaft (DE) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051805-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | disclosed |