Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL708993 | 0.63 | KDM1A (0.31) | KDM1A | |
| SCHEMBL7751743 | 0.62 | KDM1A (0.30) | KDM1A | |
| SCHEMBL455257 | 0.62 | KDM1A (0.33) | KDM1A | |
| SCHEMBL526778 | 0.60 | — | — | |
| SCHEMBL15062109 | 0.58 | KDM1A (0.43) | TLR4KDM1A | |
| SCHEMBL1234810 | 0.58 | MAPT (0.42) | KDM1A | |
| SCHEMBL130772 | 0.57 | TLR4 (0.56) | TLR4KDM1A | |
| SCHEMBL13576613 | 0.57 | KDM1A (0.42) | TLR4KDM1A | |
| SCHEMBL38654652 | 0.57 | HDAC1 (0.36) | KDM1AACHE | |
| SCHEMBL4622930 | 0.57 | HDAC1 (0.36) | KDM1AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010694-B1 | Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers | SERVIER LAB (FR) | 2003-08-06 | — | — | EP | disclosed |
| EP-1010694-A2 | Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |