Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | AGER | Q15109 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994678 | 0.91 | KCNH2 (0.49) | KCNH2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6619543 | 0.87 | MEN1 (0.53) | KCNH2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6622630 | 0.87 | MEN1 (0.53) | KCNH2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7474790 | 0.86 | KCNH2 (0.47) | KCNH2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6741300 | 0.86 | KDM4E (0.45) | KCNH2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7031260 | 0.86 | KCNH2 (0.58) | KCNH2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6733219 | 0.86 | KCNH2 (0.49) | KCNH2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6992337 | 0.86 | KCNH2 (0.50) | KCNH2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6992335 | 0.86 | KCNH2 (0.50) | KCNH2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6993770 | 0.84 | KDM4E (0.60) | KCNH2MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301510-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002004446-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-01-17 | — | — | WO | disclosed |