Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 5/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5058333 | 0.92 | AOC3 (0.53) | AOC3HTR6MEN1KMT2AALDH1A1 | |
| SCHEMBL5054839 | 0.82 | PRKDC (0.51) | MEN1KMT2AHSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL5065327 | 0.81 | PRKDC (0.50) | MEN1KMT2AHSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL7093006 | 0.76 | PRKDC (0.49) | AOC3MEN1KMT2AHSP90AA1HSP90AB1 | |
| SCHEMBL5059649 | 0.76 | PRKDC (0.55) | MEN1KMT2AALDH1A1KDM4EGAA | |
| SCHEMBL2420829 | 0.70 | IP6K1 (0.56) | MEN1KMT2AALDH1A1KDM4EGAA | |
| SCHEMBL5065308 | 0.70 | PRKDC (0.68) | MEN1KMT2AHSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL30590429 | 0.69 | PRKDC (0.71) | MEN1KMT2AALDH1A1KDM4EGAA | |
| SCHEMBL14551894 | 0.69 | PRKDC (0.71) | MEN1KMT2AALDH1A1KDM4EGAA | |
| SCHEMBL5054645 | 0.69 | PRKDC (0.58) | AOC3MEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351946-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002020500-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |