Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 7/20 | 0.62 |
| ▸ | HTR2C | P28335 | 4/20 | 0.62 |
| ▸ | HTR2A | P28223 | 2/20 | 0.62 |
| ▸ | HTR2B | P41595 | 2/20 | 0.62 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7092173 | 1.00 | KDM1A (0.62) | KDM1AHTR2CHTR2AHTR2BMAOA | |
| SCHEMBL31113521 | 1.00 | KDM1A (0.62) | KDM1AHTR2CHTR2AHTR2BMAOA | |
| SCHEMBL7864304 | 1.00 | KDM1A (0.62) | KDM1AHTR2CHTR2AHTR2BMAOA | |
| Hydrochloric Acid SCHEMBL16987811 | 0.98 | HTR2C (0.65) | KDM1AHTR2CHTR2AHTR2BMAOA | |
| Hydrochloric Acid SCHEMBL34462839 | 0.98 | HTR2C (0.65) | KDM1AHTR2CHTR2AHTR2BMAOA | |
| SCHEMBL1643778 | 0.82 | HTR2C (0.51) | KDM1AHTR2CHTR2AHTR2B | |
| SCHEMBL6745026 | 0.82 | HTR2C (0.51) | KDM1AHTR2CHTR2AHTR2B | |
| SCHEMBL1643779 | 0.82 | HTR2C (0.51) | KDM1AHTR2CHTR2AHTR2B | |
| SCHEMBL12875534 | 0.82 | HTR2C (0.59) | KDM1AHTR2CHTR2AHTR2BCA12 | |
| SCHEMBL28038759 | 0.80 | HTR2C (0.57) | KDM1AHTR2CHTR2AHTR2BCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996621-B1 | TRIAZOLO[4,5-d]PYRIMIDINE DERIVATIVES AS ANTI-THROMBOTIC AGENTS | ASTRAZENECA AB (SE) | 2003-10-01 | — | — | EP | disclosed |
| US-6251910-B1 | 1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists | ASTRAZENECA UK LIMITED (GB) | 2001-06-26 | — | — | US | disclosed |