Bis(Ethyl)Spermine

Bis(Ethyl)Spermine

SCHEMBL7092466

CCNCCCNCCCCNCCCNCC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 3/20 1.00
CYP1A2 P05177 3/20 1.00
MEN1 O00255 2/20 0.93
KMT2A Q03164 2/20 0.93
GLA P06280 1/20 0.93
KDM1A O60341 5/20 0.65
TSHR P16473 3/20 0.65
SAT1 P21673 3/20 0.62
ALDH1A1 P00352 1/20 0.59
TP53 P04637 1/20 0.47
CA12 O43570 3/20 0.44
CA2 P00918 3/20 0.44
CA4 P22748 3/20 0.44
CA6 P23280 3/20 0.44
CA5A P35218 3/20 0.44
CA7 P43166 3/20 0.44
CA9 Q16790 3/20 0.44
CA14 Q9ULX7 3/20 0.44
CA5B Q9Y2D0 3/20 0.44
CA3 P07451 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6899291 1.00 CYP2C19 (1.00) CYP2C19CYP1A2MEN1KMT2AGLA
SCHEMBL7871599 1.00 CYP2C19 (1.00) CYP2C19CYP1A2MEN1KMT2AGLA
SCHEMBL4157457 1.00 CYP2C19 (1.00) CYP2C19CYP1A2MEN1KMT2AGLA
SCHEMBL4171429 1.00 CYP2C19 (1.00) CYP2C19CYP1A2MEN1KMT2AGLA
SCHEMBL10045117 1.00 CYP2C19 (1.00) CYP2C19CYP1A2MEN1KMT2AGLA
SCHEMBL4167237 1.00 CYP2C19 (1.00) CYP2C19CYP1A2MEN1KMT2AGLA
SCHEMBL2529872 0.97 CYP2C19 (0.93) CYP2C19CYP1A2MEN1KMT2AGLA
SCHEMBL10045203 0.97 CYP2C19 (0.93) CYP2C19CYP1A2MEN1KMT2AGLA
Bis(Ethyl)Spermine SCHEMBL8526460 0.97 CYP2C19 (0.93) CYP2C19CYP1A2MEN1KMT2AGLA
SCHEMBL10045209 0.97 CYP2C19 (0.93) CYP2C19CYP1A2MEN1KMT2AGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-8217670-A None JP disclosed
US-20250270572-A1 GENE EXPRESSION ELEMENTS AND SYSTEMS AND USE THEREOF GENENEER LTD. (IL) 2025-08-28 US disclosed
US-12297438-B2 Gene expression elements and systems and use thereof GENENEER LTD. (IL) 2025-05-13 US disclosed
US-20250140406-A1 CLASSIFYING TUMORS AND PREDICTING RESPONSIVENESS INSIGHT MOLECULAR DIAGNOSTICS INC. 2025-05-01 US disclosed
US-20240309418-A1 ENZYMATIC METHODS AND COMPOSITIONS FOR POLYMERIZATION OF PHOSPHORAMIDATE AND THIOPHOSPHORAMIDATE-LINKED DNA MASSACHUSETTS GEN HOSPITAL (US) 2024-09-19 US disclosed
WO-2024192269-A2 ENZYMATIC METHODS AND COMPOSITIONS FOR POLYMERIZATION OF PHOSPHORAMIDATE AND THIOPHOSPHORAMIDATE-LINKED DNA THE GENERAL HOSPITAL CORPORATION (US) 2024-09-19 WO disclosed
US-20220244263-A1 METHODS FOR TREATING SMALL CELL NEUROENDOCRINE AND RELATED CANCERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-08-04 US disclosed
US-20220087987-A1 A METHOD FOR TREATING SWI/SNF COMPLEX-DEFICIENT CANCERS COMPRISING GLUTATHIONE (GSH) METABOLIC PATHWAY INHIBITOR NATIONAL CANCER CENTER (JP) 2022-03-24 US disclosed
EP-3971178-A1 AMINOQUINOLINE DERIVATIVES AND USES THEREOF The McLean Hospital Corporation (US) 2022-03-23 EP disclosed
US-20220064656-A1 GENE EXPRESSION ELEMENTS AND SYSTEMS AND USE THEREOF GENENEER LTD. (IL) 2022-03-03 US disclosed
US-7235695-B2 Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor SLIL BIOMEDICAL CORPORATION 2007-06-26 US disclosed
US-7235695-B2 Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor SLIL BIOMEDICAL CORPORATION 2007-06-26 US disclosed
US-6627399-B1 Using compound of given formula as accelerator RIKEN (JP) 2003-09-30 US disclosed
US-6605645-B2 Such as 1,15-di(cyclopropylmethylamino)-8-benzyl-4,8,12-triazapentadecane; carcinostatic action RIKEN (JP) 2003-08-12 US disclosed
US-20030073202-A1 RNA polymerase transcription promoter and nucleic acid sequencing method IWATA MASAAKI (JP) 2003-04-17 US disclosed
US-20020067472-A1 Linear polyamine compounds and polyamine anticancer agents IWATA MASAAKI (JP) 2002-06-06 US disclosed
US-6319956-B1 N1, N4-BIS(CYCLOPROPYLMETHYLAMINO)TRIALKYLENETETRAMINES THAT MAY BE TOLUENESULFONATED. RIKEN (JP) 2001-11-20 US disclosed
EP-1061130-A1 RNA POLYMERASE TRANSCRIPTION PROMOTERS AND METHOD FOR DETERMINING BASE SEQUENCE Riken (JP) 2000-12-20 EP disclosed
US-6114394-A Polyamine derivatives as radioprotective agents MERRELL PHARMACEUTICALS INC. (US) 2000-09-05 US disclosed
JP-H08217670-A AMELIORANT FOR CEREBRAL FUNCTION MEIJI SEIKA KAISHA LTD 1996-08-27 JP disclosed