Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.91 |
| ▸ | CCNC | P24863 | 5/20 | 0.60 |
| ▸ | CDK8 | P49336 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.59 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.59 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | GABRP | O00591 | 2/20 | 0.59 |
| ▸ | GABRD | O14764 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5063530 | 0.96 | PRKDC (1.00) | PRKDCCCNCCDK8MAPTABCB1 | |
| SCHEMBL29492842 | 0.96 | PRKDC (1.00) | PRKDCCCNCCDK8MAPTABCB1 | |
| SCHEMBL5058392 | 0.94 | PRKDC (0.80) | PRKDCCCNCCDK8MAPTABCB1 | |
| SCHEMBL28762682 | 0.86 | PRKDC (0.81) | PRKDCCCNCCDK8MAPTABCB1 | |
| SCHEMBL5058357 | 0.83 | PRKDC (0.77) | PRKDCCCNCCDK8MAPTABCB1 | |
| SCHEMBL5055259 | 0.82 | PRKDC (0.74) | PRKDCCCNCCDK8MAPTABCB1 | |
| SCHEMBL5063525 | 0.82 | PRKDC (0.74) | PRKDCCCNCCDK8MAPTABCB1 | |
| SCHEMBL5054842 | 0.81 | PRKDC (0.74) | PRKDCCCNCCDK8MAPTABCB1 | |
| SCHEMBL5054849 | 0.76 | PRKDC (0.67) | PRKDCMAPTABCB1CYP3A4MEN1 | |
| SCHEMBL7089208 | 0.76 | PRKDC (0.54) | PRKDCCCNCCDK8MAPTABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351946-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002020500-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |