Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 12/20 | 0.68 |
| ▸ | KDR | P35968 | 9/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.68 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.68 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.68 |
| ▸ | TLK2 | Q86UE8 | 4/20 | 0.68 |
| ▸ | RIOK2 | Q9BVS4 | 2/20 | 0.68 |
| ▸ | TLK1 | Q9UKI8 | 2/20 | 0.68 |
| ▸ | EGFR | P00533 | 2/20 | 0.68 |
| ▸ | PLK4 | O00444 | 2/20 | 0.68 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.68 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.68 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.68 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.68 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.68 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.68 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.68 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.68 |
| ▸ | INSR | P06213 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4498904 | 1.00 | PDGFRB (0.68) | PDGFRBKDRFGFR1PRKAA1PRKAA2 | |
| SCHEMBL4498901 | 1.00 | PDGFRB (0.68) | PDGFRBKDRFGFR1PRKAA1PRKAA2 | |
| SCHEMBL4498906 | 0.94 | PDGFRB (0.68) | PDGFRBKDRFGFR1PRKAA1PRKAA2 | |
| SCHEMBL4498902 | 0.94 | PDGFRB (0.68) | PDGFRBKDRFGFR1PRKAA1PRKAA2 | |
| SCHEMBL13712023 | 0.94 | PDGFRB (0.68) | PDGFRBKDRFGFR1PRKAA1PRKAA2 | |
| SCHEMBL4492147 | 0.91 | PDGFRB (0.82) | PDGFRBKDRFGFR1PRKAA1PRKAA2 | |
| SCHEMBL4503839 | 0.91 | PDGFRB (0.82) | PDGFRBKDRFGFR1PRKAA1PRKAA2 | |
| SCHEMBL4489865 | 0.91 | KDR (0.68) | PDGFRBKDRFGFR1PRKAA1PRKAA2 | |
| SCHEMBL4489871 | 0.91 | KDR (0.68) | PDGFRBKDRFGFR1PRKAA1PRKAA2 | |
| SCHEMBL6726631 | 0.90 | PDGFRB (0.83) | PDGFRBKDRFGFR1PRKAA1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370554-A1 | 3-(4-AMIDOPYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2003-12-17 | — | — | EP | claimed |
| WO-2002066463-A1 | 3-(4-AMIDOPYRROL-2-YLMETHLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2002-08-29 | — | — | WO | claimed |