Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 3/20 | 0.71 |
| ▸ | CDK1 | P06493 | 3/20 | 0.71 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.71 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.71 |
| ▸ | JAK1 | P23458 | 7/20 | 0.61 |
| ▸ | TYK2 | P29597 | 7/20 | 0.61 |
| ▸ | JAK2 | O60674 | 7/20 | 0.61 |
| ▸ | JAK3 | P52333 | 5/20 | 0.61 |
| ▸ | F12 | P00748 | 2/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | STK25 | O00506 | 1/20 | 0.50 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.50 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1248143 | 0.90 | CCNB2 (0.77) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL1248356 | 0.86 | CCNB2 (0.65) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL1250806 | 0.85 | CCNB2 (0.67) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL1167320 | 0.84 | CCNB2 (0.62) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL1167929 | 0.84 | CCNB2 (0.65) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL1249224 | 0.84 | CCNB2 (0.65) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL5726202 | 0.83 | CCNB2 (1.00) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL1167961 | 0.82 | CCNB2 (0.62) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL5964782 | 0.81 | TYK2 (0.62) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL1248362 | 0.81 | TYK2 (0.63) | CCNB2CDK1CCNB1CCNB3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355889-A1 | SUBSTITUTED TRIAZOLE DIAMINE DERIVATIVES AS KINASE INHIBITORS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002057240-A1 | SUBSTITUTED TRIAZOLE DIAMINE DERIVATIVES AS KINASE INHIBITORS | ORTHO MC NEIL PHARMACEUTICAL, INC. (US) | 2002-07-25 | — | — | WO | disclosed |