Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 8/20 | 0.68 |
| ▸ | NOTCH3 | Q9UM47 | 8/20 | 0.68 |
| ▸ | CCKBR | P32239 | 4/20 | 0.59 |
| ▸ | NOTCH2 | Q04721 | 1/20 | 0.58 |
| ▸ | NOTCH4 | Q99466 | 1/20 | 0.58 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.56 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.56 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.56 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.56 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.56 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.56 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.56 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6005367 | 0.94 | NOTCH1 (0.68) | NOTCH1NOTCH3CCKBRNOTCH2NOTCH4 | |
| SCHEMBL6005122 | 0.94 | NOTCH1 (0.68) | NOTCH1NOTCH3CCKBRNOTCH2NOTCH4 | |
| SCHEMBL6003918 | 0.92 | NOTCH1 (0.65) | NOTCH1NOTCH3CCKBRNOTCH2NOTCH4 | |
| SCHEMBL6005174 | 0.90 | NOTCH1 (0.66) | NOTCH1NOTCH3CCKBRNOTCH2NOTCH4 | |
| SCHEMBL6005727 | 0.90 | NOTCH1 (0.66) | NOTCH1NOTCH3CCKBRNOTCH2NOTCH4 | |
| SCHEMBL6005158 | 0.88 | NOTCH1 (0.60) | NOTCH1NOTCH3CCKBRNOTCH2NOTCH4 | |
| SCHEMBL6006185 | 0.87 | NOTCH1 (0.62) | NOTCH1NOTCH3CCKBRNOTCH2NOTCH4 | |
| SCHEMBL6005055 | 0.85 | NOTCH1 (0.68) | NOTCH1NOTCH3CCKBRNOTCH2NOTCH4 | |
| SCHEMBL6004975 | 0.83 | PSEN1 (0.67) | NOTCH1NOTCH3CCKBRPSEN1PSEN2 | |
| SCHEMBL6005868 | 0.83 | PSEN1 (0.67) | NOTCH1NOTCH3CCKBRPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294702-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LTD. (GB) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001090084-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-11-29 | — | — | WO | disclosed |