Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.41 |
| ▸ | KIT | P10721 | 4/20 | 0.41 |
| ▸ | GRK5 | P34947 | 5/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 4/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.35 |
| ▸ | FLT3 | P36888 | 4/20 | 0.35 |
| ▸ | PLK4 | O00444 | 3/20 | 0.35 |
| ▸ | DCLK1 | O15075 | 3/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.35 |
| ▸ | RPS6KA4 | O75676 | 3/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7089459 | 0.90 | KDR (0.41) | KDRPDGFRBKITGRK5CSF1R | |
| SCHEMBL7094761 | 0.90 | KDR (0.42) | KDRPDGFRBKITGRK5CSF1R | |
| SCHEMBL4480902 | 0.81 | KDR (0.52) | KDRPDGFRBKITGRK5CSF1R | |
| SCHEMBL4480891 | 0.81 | KDR (0.52) | KDRPDGFRBKITGRK5CSF1R | |
| SCHEMBL13712800 | 0.76 | KDR (0.48) | KDRPDGFRBKITGRK5BACE1 | |
| SCHEMBL4492209 | 0.72 | GRK5 (0.56) | KDRPDGFRBKITGRK5CSF1R | |
| SCHEMBL4492200 | 0.72 | GRK5 (0.56) | KDRPDGFRBKITGRK5CSF1R | |
| SCHEMBL4484698 | 0.70 | KDR (0.58) | KDRPDGFRBKITGRK5CSF1R | |
| SCHEMBL4484690 | 0.70 | KDR (0.58) | KDRPDGFRBKITGRK5CSF1R | |
| SCHEMBL4495580 | 0.69 | GRK5 (0.53) | KDRPDGFRBKITGRK5CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370554-A1 | 3-(4-AMIDOPYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2003-12-17 | — | — | EP | claimed |
| WO-2002066463-A1 | 3-(4-AMIDOPYRROL-2-YLMETHLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2002-08-29 | — | — | WO | claimed |