Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5059591 | 0.93 | PRKDC (0.57) | PRKDCALDH1A1FLT3KDM4EPIK3CA | |
| SCHEMBL5058586 | 0.85 | PRKDC (0.67) | PRKDCALDH1A1KDM4EPIK3CAPIK3CD | |
| SCHEMBL5058582 | 0.81 | PRKDC (0.61) | PRKDCALDH1A1KDM4EPIK3CAPIK3CD | |
| SCHEMBL11921366 | 0.77 | PRKDC (0.61) | PRKDCALDH1A1KDM4EPIK3CAPIK3CD | |
| SCHEMBL5054620 | 0.75 | PRKDC (0.58) | PRKDCPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL5054845 | 0.73 | PRKDC (0.61) | PRKDCPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL5058382 | 0.73 | PRKDC (0.72) | PRKDCALDH1A1KDM4EPIK3CAPIK3CD | |
| SCHEMBL5054826 | 0.73 | PRKDC (0.72) | PRKDCALDH1A1KDM4EPIK3CAPIK3CD | |
| SCHEMBL5058550 | 0.71 | PRKDC (0.69) | PRKDCPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL5054595 | 0.71 | PRKDC (0.65) | PRKDCALDH1A1KDM4EPIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351946-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002020500-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |