Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 7/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.50 |
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12567897 | 0.86 | KDR (0.74) | NPC1KDRCDK1CDK2CHEK1 | |
| SCHEMBL7089728 | 0.82 | NPC1 (0.81) | NPC1KDRCDK1CDK2CHEK1 | |
| SCHEMBL6954274 | 0.74 | KDR (0.61) | NPC1KDRCDK1CDK2CHEK1 | |
| SCHEMBL11861088 | 0.74 | KDR (0.56) | NPC1KDRCDK1CDK2CHEK1 | |
| SCHEMBL7093471 | 0.73 | NPC1 (0.58) | NPC1KDRCDK1CDK2CHEK1 | |
| SCHEMBL7092676 | 0.73 | NPC1 (0.58) | NPC1KDRCDK1CDK2CHEK1 | |
| SCHEMBL7092678 | 0.73 | NPC1 (0.61) | NPC1KDRCDK1CDK2CHEK1 | |
| SCHEMBL29819445 | 0.72 | KDR (1.00) | NPC1KDRCDK1CDK2CHEK1 | |
| SCHEMBL6968182 | 0.72 | KDR (1.00) | NPC1KDRCDK1CDK2CHEK1 | |
| SCHEMBL11865968 | 0.71 | NPC1 (0.53) | NPC1KDRCDK1CDK2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1335836-A | Tricyclic pyrazole derivatives | BASF AG (DE) | 2002-02-13 | — | — | CN | claimed |
| EP-1127051-A2 | TRICYCLIC PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2001-08-29 | — | — | EP | claimed |
| WO-2000027822-A2 | TRICYCLIC PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-18 | — | — | WO | claimed |
| EP-1289525-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2003-03-12 | — | — | EP | disclosed |
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |
| CN-1335836-A | Tricyclic pyrazole derivatives | BASF AG (DE) | 2002-02-13 | — | — | CN | disclosed |
| WO-2001087846-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-11-22 | — | — | WO | disclosed |
| EP-1127051-A2 | TRICYCLIC PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000027822-A2 | TRICYCLIC PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-18 | — | — | WO | disclosed |