Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 12/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7095422 | 1.00 | TNF (0.46) | TNFMEN1KMT2ACNR2GAA | |
| SCHEMBL7095386 | 0.89 | KMT2A (0.49) | MEN1KMT2AGAANPSR1EP300 | |
| SCHEMBL7095388 | 0.89 | KMT2A (0.49) | MEN1KMT2AGAANPSR1EP300 | |
| SCHEMBL7097076 | 0.84 | KAT2B (0.46) | KMT2AGAANPSR1EP300CREBBP | |
| SCHEMBL7098771 | 0.84 | KAT2B (0.46) | KMT2AGAANPSR1EP300CREBBP | |
| SCHEMBL7097429 | 0.82 | KAT2B (0.42) | KMT2ACNR2GAANPSR1EP300 | |
| SCHEMBL7097428 | 0.82 | KAT2B (0.42) | KMT2ACNR2GAANPSR1EP300 | |
| SCHEMBL7096891 | 0.82 | POLB (0.48) | MEN1KMT2AGAANPSR1EP300 | |
| SCHEMBL7096892 | 0.82 | POLB (0.48) | MEN1KMT2AGAANPSR1EP300 | |
| SCHEMBL7096022 | 0.82 | KAT2B (0.46) | MEN1KMT2AGAANPSR1EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0878196-B1 | KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| US-6133258-A | PYRIDOTHIAZINE DERIVATIVE; FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS, MULTIPLE SCLEROSIS, PAIN, GLAUCOMA | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-17 | — | — | US | disclosed |
| EP-0878196-A1 | KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-11-18 | — | — | EP | disclosed |