Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | PDE2A | O00408 | 1/20 | 0.57 |
| ▸ | PDE9A | O76083 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.57 |
| ▸ | PDE6C | P51160 | 1/20 | 0.57 |
| ▸ | PDE1A | P54750 | 1/20 | 0.57 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.57 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7096759 | 0.92 | PDE5A (0.66) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL7099829 | 0.89 | KDM4E (0.61) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL7001170 | 0.86 | KDM4E (0.58) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL7092194 | 0.84 | KDM4E (0.65) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL7092377 | 0.82 | PDE5A (0.60) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL7001089 | 0.81 | KDM4E (0.61) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL7002311 | 0.81 | KDM4E (0.62) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL7005470 | 0.80 | KDM4E (0.60) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL7096090 | 0.80 | PDE5A (0.60) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL7096466 | 0.80 | PDE5A (0.67) | PDE5AKDM4EPDE2APDE9APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129093-B1 | PYRAZOLOPYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF IMPOTENCE | DONG A PHARM CO LTD (KR) | 2003-07-23 | — | — | EP | claimed |